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801Averting comfortable lifestyle crises - How have climate change and diet shaped the evolution of human energy metabolism, and responses to Vitamin C, fructose and uric acid? Studies have revealed the flexibility of human metabolism in response to partial and total starvation and demonstrated that type 2 diabetics were better adapted than healthy subjects to conserving protein during fasting. The industrialisation of food processing in the C20 has led to increases in palatability and digestibility with a parallel loss of quality leading to overconsumption and the current obesity epidemic. New approaches are needed to the chronology of eating, the health benefits of intermittent fasting and the role of diet and exercise in the maintenance of a healthy human microbiome.